ovariancancer.jhmi.eduOvarian Cancer & Ovarian Pathology - Ovarian Cancer  |  Johns Hopkins Pathology

Ovarian Cancer & Ovarian Pathology - Ovarian Cancer | Johns Hopkins Pathology You are using an unsupported version of IE. This site will work on IE9+. ▲ Pathology Home - Toggle navigation ✕ OvCa Basics You Should Know Ovarian Overview Symptoms & Risk Factors Explain My Results Understanding My Report Types of Ovarian Tumors Staging My Options Second Opinions Treatment Options Clinical Trials The Pathologist’s Role Our Team Home Patient Stories Glossary Tribute Donate Home Patient Stories Glossary Tribute Donate OvCa Basics You Should Know Ovarian Overview Symptoms & Risk Factors Explain My Results Understanding My Report Types of Ovarian Tumors Staging My Options Second Opinions Treatment Options Clinical Trials The Pathologist’s Role Our Team Ovarian Cancer & Ovarian Pathology Ovarian Cancer Ovarian cancer is a group of diseases that originate in the ovaries, or in the related areas of the fallopian tubes and the peritoneum. The ovaries are a woman’s reproductive organs. Women have two ovaries that are located in the pelvis—one on each side of the uterus. The ovaries have a size and shape comparable to a large olive. The role of the ovaries is to produce eggs and also the female hormones. Learn More Contact Us Getting a second opinion on your pathology diagnosis can clarify or even change a diagnosis. This can affect prognosis as well as therapy, and adds important data that contributes to a larger cause: making sure every diagnosis of ovarian cancer, everywhere, is as accurate as possible. Get a Second Opinion Your Results Your Pathologist will use slides to help determine the following about a tumor: whether it is benign or malignant the stage and grade Learn More Our Expertise Diagnosing and treating breast cancer is truly a multidisciplinary team effort. The Gynecologic Pathology Service is one integral part of the comprehensive, patient-centered team approach to ovarian cancer at Johns Hopkins. Meet Our Team Tribute to Sean Patrick On January 20, 2009, our dear friend Sean Patrick succumbed to ovarian cancer after a battle of more than 12 years. She fought the disease personally, as well as for all women. Read More About Sean 55-64 Women in this age range have higher rates of ovarian cancer ~22,000 New cases of ovarian cancer diagnosed in 2018 1 in 79 A woman’s lifetime risk of developing invasive ovarian cancer © 2020 Johns Hopkins University OvCa Basics Explain My Results My Options The Pathologist’s Role Our Team Historically defined as disease recurrence within 6 months of completion of first-line platinum-based chemotherapy, although this is now more broadly applied to also include patients progressing within 6 months after multiple lines of chemotherapy. (of cells or tissues) Obtained from the same individual. The degree to which a substance (a toxin or poison) can harm humans. This chemotherapy technique delivers chemotherapy drugs directly into the abdominal cavity through a catheter (thin tube). A surgical procedure that removes your uterus through an incision in your lower abdoman. Also known as a BSO, is a surgical procedure in which both of the ovaries and the fallopian tubes are removed. A surgical procedure designed to remove the omentum, which is a thin fold of abdominal tissue that encases the stomach, large intestine and other abdominal organs. Removal of the affected ovary and fallopian tube. A primary ovarian tumor with features similar to those of the kidney tumor of the same name. Also called sonography or diagnostic medical sonography, is an imaging method that uses high-frequency sound waves to produce images of structures within your body. The images can provide valuable information for diagnosing and treating a variety of diseases and conditions. A multidisciplinary meeting of the physicians and caretakers involved in cancer care, including pathologists , surgical oncologists, medical oncologists, radiologists, nurses and genetic counselors to discuss the treatment plans for individual patients. A mass or a lump. A tumor mass can be nonneoplastic and be due to something like swelling or inflammation. A tumor mass can also be neoplastic, and includes both benign and malignant tumors. The process by which the body reads the code in RNA to make proteins. An inflammatory mass found in the fallopian tube, ovary and adjacent pelvic organs. Thecomas are stromal tumors containing a significant number of cells with appreciable cytoplasm resembling to varying degrees theca cells. The process by which DNA is copied to make RNA . A type of treatment that specifically targets a single molecule or pathway involved in cancer cell growth and progression. A mature teratoma composed either exclusively or predominantly of thyroid tissue. Any change noted by a patient that could be caused by a disease. A disease that widely affects the entire body. A treatment that can reach cancer cells that have potentially spread throughout the body. Examples include chemotherapy, hormone therapy, and targeted therapy. Systemic therapies can have side effects due to effects on normal body cells, such as hair loss or gastrointestinal distress. A tumor composed entirely of cells resembling steroid-secreting cells that lack Reinke crystals. A non-neoplastic, benign proliferation of ovarian stromal cells without associated luteinized stromal cells. Presence of luteinized cells in the ovarian stroma, typically associated with stromal hyperplasia. A gene mutation that occurs spontaneously in the body tissues or in the cancer cells that cannot be passed on to offspring (i.e., it cannot be inherited). A measure of how much a cancer has grown and/or spread in the body (i.e., how advanced a cancer is). The most common staging system is the TNM system, which stands for T umor, lymph N odes, and M etastasis. FIGO stage is based on the International Federation of Gynecology and Obstetrics system. The term for the usual treatment given for a particular disease, which is based on past research and experience proving the treatment’s efficacy and safety. An uncommon, sex cord-stromal tumor with a distinctive pattern of simple and complex annular tubules. A benign, stromal tumor containing cells with signet-ring morphology but without intracytoplasmic mucin, glycogen or lipid, in a background fibromatous stroma. An undifferentiated neoplasm, predominantly composed of small cells, but occasionally with a large cell component, and which is often associated with paraneoplastic hypercalcemia. The tumor is unrelated to small cell carcinoma of neuroendocrine (pulmonary) type. These tumors are characterized by epithelial cell types resembling those of the fallopian tube, including ciliated cells. The epithelial component may be associated with a prominent component of stromal cells (cystadenofibroma, adenofibroma), may lack a stromal component (cystadenoma) or be entirely a surface papillary lesion (surface papilloma). Combinations of these growth patterns occur. A neoplasm composed of Sertoli cells arranged in a variety of patterns, but most commonly as hollow or solid tubules. Tumors are composed of variable proportions of Sertoli cells, Leydig cells and in the case of moderately and poorly differentiated neoplasms, primitive gonadal stroma and sometimes heterologous elements. The process of having a second set of doctors look at your unique medical situation to provide a second opinion on the diagnosis and/or treatment plan. A benign cystic neoplasm with two or more Müllerian cell types, all accounting for at least 10% of the epithelium. Rare tumors have more prominent fibrous stroma (adenofibroma). A carcinoma composed predominantly of serous and endocervical-type mucinous epithelium. Foci containing clear cells and areas of endometrioid and squamous differentiation are not uncommon. mRNA molecules are a copy of the genetic information encoded in DNA, and the RNA copy is then used to create proteins. A cancer that arises from the connective tissue of...